Otselic is a town in Chenango County, New York, United States, situated on the northern border of Chenango County, northwest of the city of Norwich. The population of the town was 1,054 at the 2010 census. The town is named after a river flowing through it, the Otselic, which is an Oneida word for "place of wild plums". The Otselic valley is the predominant geographic feature in the town, connecting it to the surrounding region north and south.

Chenango County is a county located in the south-central section U.S. state of New York. As of the 2020 census, the population was 47,220. Its county seat is Norwich. The county's name originates from an Oneida word meaning 'large bull-thistle'. The county is part of the Southern Tier region of the state.