Otto Gunther Octavius is a fictional character portrayed by Alfred Molina in Spider-Man 2 (2004) and later in the Marvel Cinematic Universe (MCU) film Spider-Man: No Way Home (2021), based on the Marvel Comics character of the same name. Octavius is introduced in Spider-Man 2 as a nuclear physicist and friend and mentor of Peter Parker, whose research into fusion power with his wife Rosie is being sponsored by Oscorp's genetic and scientific research division, headed by Harry Osborn.

Alfred Molina is a British actor. He is known for his leading roles and character actor roles on the stage and screen. In a career spanning over five decades he has received a Drama Desk Award as well as nominations for two BAFTA Awards, a British Independent Film Award, an Independent Spirit Award, five Screen Actors Guild Awards, and three Tony Awards.