The Our Lady of Grace Cathedral, also called Cathedral of São Tomé, is a church in the city of São Tomé, capital of the African and island country of São Tomé and Príncipe. It is the cathedral of the Roman Catholic Diocese of São Tomé and Príncipe. It stands at Praça do Povo in the city centre, close to the Presidential Palace.

São Tomé is the capital and largest city of the Central African island country of São Tomé and Príncipe. Its name is Portuguese for "Saint Thomas". Founded in the 15th century, it is one of Africa's oldest colonial cities.