Our Lady of Guadalupe Catholic Church is a Roman Catholic church located in the Second Ward in the East End, Houston, Texas. It is a part of the Roman Catholic Archdiocese of Galveston-Houston.

Second Ward is a historical political district ward in the East End community in Houston, Texas. It was one of the four original wards of the city in the nineteenth century. The community known as the Second Ward today is roughly bounded by Buffalo Bayou to the north, Lockwood Avenue to the east, and railroad tracks to the south and west, although the City of Houston's "Super Neighborhood" program includes a section east of Lockwood.