The Pánuco River, also known as the Río de Canoas, is a river in Mexico fed by several tributaries including the Moctezuma River and emptying into the Gulf of Mexico. The river is approximately 510 kilometres (320 mi) long and passes through or borders the states of Mexico, Hidalgo, Querétaro, San Luis Potosí, Tamaulipas, and Veracruz. According to the Atlas of Mexico, it is the fourth-largest river in Mexico by volume of runoff, and forms the sixth-largest river basin in Mexico by area.

The Gulf of Mexico is an ocean basin and a marginal sea of the Atlantic Ocean, mostly surrounded by the North American continent. It is bounded on the northeast, north and northwest by the Gulf Coast of the United States; on the southwest and south by the Mexican states of Tamaulipas, Veracruz, Tabasco, Campeche, Yucatán, and Quintana Roo; and on the southeast by Cuba. The Southern U.S. states of Texas, Louisiana, Mississippi, Alabama, and Florida, which border the gulf on the north, are often referred to as the "Third Coast" of the United States.