The P.E.O. Sisterhood is a U.S.-based international women's organization of about 197,000 members, with a primary focus on providing educational opportunities for female students worldwide. The Sisterhood is headquartered in Des Moines, Iowa, with chapters throughout the United States and Canada. Among other projects, it owns and supports Cottey College, an independent college for women in Nevada, Missouri.

Cottey College is a private women's college in Nevada, Missouri. It was founded by Virginia Alice (Cottey) Stockard in 1884. Since 1927 it has been owned and supported by the P.E.O. Sisterhood, a philanthropic women's organization based in Des Moines, Iowa. For most of its history, Cottey was a two-year liberal arts college, and in 2011 it achieved accreditation as a four-year baccalaureate-granting college. It had 266 students enrolled in 2023.