The PC-461-class submarine chasers were a class of 343 submarine chasers constructed mainly for the US Navy and built from 1941 to 1944. The PC-461s were based primarily on two experimental submarine chasers, PC-451 and PC-452. While PC-461 began the series, the first of the class to enter service was PC-471. As part of the Lend-Lease program, 46 ships of this class were transferred to allies of the United States. Fifty-nine PC-461s were converted to other types of patrol vessels. Eight vessels of this class were lost, and one vessel was lost after conversion to a PGM-9-class motor gunboat. Only one of the class, USS PC-566 commanded by Lieutenant Commander Herbert G. Claudius, actually sank a submarine, U-166, during World War II; however, the website 'Patrol Craft Sailors Association' cites PC-461-class ships sinking or assisting sinking up to 6 German and Japanese subs.

A submarine chaser or subchaser is a small naval vessel that is specifically intended for anti-submarine warfare. Many of the American submarine chasers used in World War I found their way to Allied nations by way of Lend-Lease in World War II.