The PFL 6 mixed martial arts event for the 2022 season of the Professional Fighters League was held on July 1, 2022, at the Overtime Elite Arena in Atlanta, Georgia. This marked the sixth regular season event of the tournament and included fights in the Women's Lightweight and Welterweight divisions.

Kayla Harrison is an American professional mixed martial artist and multiple Olympic gold medalist and world champion judoka. She currently competes in the Women’s Bantamweight division in the Ultimate Fighting Championship (UFC). As of April 16, 2024, she is #4 in the UFC women's bantamweight rankings, and as of May 7, 2024, she is #14 in the UFC women's pound-for-pound rankings.