PNA Azopardo (GC-25) is a Mantilla-class patrol boat of the Argentine Naval Prefecture, built at the Empresa Nacional Bazán shipyards and commissioned in 1983. The vessel is named after Juan Bautista Azopardo, a Maltese privateer and officer of the Argentine Navy during the Independence and Cisplatine wars, and Harbourmaster of Buenos Aires; she is the second PNA ship with this name.

The Argentine Naval Prefecture is a service of Argentina's Security Ministry charged with protecting the country's rivers and maritime territory. It therefore fulfills the functions of other countries' coast guards, and furthermore acts as a gendarmerie force policing navigable rivers.