Pacific Northwest National Laboratory (PNNL) is one of the United States Department of Energy national laboratories, managed by the Department of Energy's (DOE) Office of Science. The main campus of the laboratory is in Richland, Washington, with additional research facilities around the country.

The United States Department of Energy National Laboratories and Technology Centers is a system of laboratories overseen by the United States Department of Energy (DOE) for scientific and technological research. The primary mission of the DOE national laboratories is to conduct research and development (R&D) addressing national priorities: energy and climate, the environment, national security, and health. Sixteen of the seventeen DOE national laboratories are federally funded research and development centers administered, managed, operated and staffed by private-sector organizations under management and operating (M&O) contracts with the DOE. The National Laboratory system was established in the wake of World War II, during which the United States had quickly set-up and pursued advanced scientific research in the sprawling Manhattan Project.