The Padang Besar railway station is a railway station located at and named after the border town of Padang Besar, Perlis in Malaysia. It is the northernmost station of the west coast line where the line connects to the State Railway of Thailand's rail network via its Southern Line.

Padang Besar is a border town located in the northern part of the state of Perlis in Malaysia as well northmost town in Malaysia. It is situated on the border with Songkhla province, Thailand, 35 kilometers northeast of Kangar and about 57 km southwest of Hat Yai. The town opposite Padang Besar in Thailand is also known as Padang Besar, although the locals here usually refer to the town as "Pekan Siam" or Siamese town. The town is a "shopping heaven" and popular destination for Malaysians because of the duty-free shopping complex in between the border checkpoints of the two countries. The town attracts several thousand visitors from Peninsular Malaysia and southern Thailand every weekend and during public holidays.