Paderborn Hauptbahnhof is the main passenger station in the city of Paderborn in the German state of North Rhine-Westphalia. It is located on the Hamm–Warburg line, part of the Mid-Germany Connection from Cologne or Düsseldorf to Thuringia and Saxony. The Senne Railway branches off to Bielefeld in Paderborn.

Paderborn is a city in eastern North Rhine-Westphalia, Germany, capital of the Paderborn district. The name of the city derives from the river Pader and Born, an old German term for the source of a river. The river Pader originates in more than 200 springs near Paderborn Cathedral, where St. Liborius is buried.