Pago Bay is the largest bay on the U.S. territory of Guam, located at the mouth of Pago River on the island's eastern coast. There is extensive evidence of CHamoru settlement before Spanish colonization during the late seventeenth century. During the Spanish-Chamorro Wars, the Spanish transferred the populations of Tinian and Aguigan to the village of Pago. However, a smallpox epidemic in 1856 killed much of the village's population and the Spanish moved survivors to other villages, leaving the bay shoreline largely uninhabited. The bay is popular with fishermen and recreationalists, and was the site of new housing development in the 2000s.

The Spanish–Chamorro Wars, also known as the Chamorro Wars and the Spanish–Chamorro War, refer to the late seventeenth century unrest among the Chamorros of the Mariana Islands in the western Pacific Ocean against the colonial effort of Habsburg Spain. Anger at proselytizing by the first permanent mission to Guam, which was led by Diego Luis de San Vitores, and a series of cultural misunderstandings led to increasing unrest on Guam and a Chamorro siege of the Hagåtña presidio incited by maga'låhi (Chief) Hurao in 1670. Maga'låhi Matå'pang killed San Vitores in 1672, resulting in a campaign of Spanish reprisal burnings of villages through 1676. Local anger at the attacks against villages resulted in another open rebellion led by Agualin and a second siege of Hagåtña. Governor Juan Antonio de Salas conducted a counter-insurgency campaign that successfully created a system of collaboration in which Guamanians turned in rebels and murderers and transferred most of the people from about 180 villages to seven towns, a policy known as reducción. By the early 1680s, Guam was largely "reduced," or pacified.