The Palace of Shaki Khans in Shaki, Azerbaijan, was a summer residence for the Shaki khans. It was built in 1797 by Muhammad Husayn Khan Mushtaq. The palace was intended to house the khans who were in charge of controlling Shaki, as viceroys of the ruling Zand and later Qajar Persian dynasties around 1750 until the time when these territories were annexed by the Russian Empire per the treaty of Gulistan in 1813 after the Russo-Persian War (1804–1813).

Shaki is a city in northwestern Azerbaijan, surrounded by the district of the same name. It is located in the southern part of the Greater Caucasus mountain range, 240 km (150 mi) from Baku. As of 2020, it has a population of 68,400. The center of the city and the Palace of Shaki Khans were inscribed in the UNESCO World Heritage List in 2019 because of their unique architecture and history as an important trading center along the Silk Road.