The Palace of San Telmo is a historical edifice in Seville, southern Spain, formerly the Universidad de Mareantes, now is the seat of the presidency of the Andalusian Autonomous Government. Construction of the building began in 1682 outside the walls of the city, on property belonging to the Tribunal of the Holy Office, the institution responsible for the Spanish Inquisition. It was originally constructed as the seat of the University of Navigators, a school to educate orphaned children and train them as sailors.

Seville is the largest city of the Spanish autonomous community of Andalusia and the province of Seville. It is situated on the lower reaches of the River Guadalquivir, in the southwest of the Iberian Peninsula.