Palermo Cathedral is the cathedral church of the Roman Catholic Archdiocese of Palermo, located in Palermo, Sicily, southern Italy. It is dedicated to the Assumption of the Virgin Mary. As an architectural complex, it is characterized by the presence of different styles, due to a long history of additions, alterations and restorations, the last of which occurred in the 18th century.

The Metropolitan Archdiocese of Palermo is a Latin diocese of the Catholic Church. It was founded as the Diocese of Palermo in the first century and raised to the status of archdiocese in the 11th century. The archbishop is Corrado Lorefice.