Palestine is a city in and the seat of Anderson County in the U.S. state of Texas. It was named after Palestine, Illinois, by preacher Daniel Parker, who had migrated from that town. It is also contested that Micham Main named Palestine after his hometown, also Palestine, Illinois, when he and his family arrived here along with the Parker family and several others.

Anderson County is a county in the U.S. state of Texas. Located within East Texas, its county seat is Palestine. As of the 2020 United States census, the population of Anderson County was 57,922. Anderson County comprises the Palestine micropolitan statistical area. Anderson County was organized in 1846, and was named after Kenneth Lewis Anderson (1805-1845), the last vice president of the Republic of Texas.