The Palestra, often called the Cathedral of College Basketball, is a historic arena and the home gym of the Penn Quakers men's and women's basketball teams, volleyball teams, wrestling team, and Philadelphia Big 5 basketball. Located at 235 South 33rd St. in Philadelphia, Pennsylvania on the campus of the University of Pennsylvania, near Franklin Field in the University City section of Philadelphia, it opened on January 1, 1927. The Palestra has been called "the most important building in the history of college basketball" and "changed the entire history of the sport for which it was built".

The Penn Quakers are the athletic teams of the University of Pennsylvania. The school sponsors 33 varsity sports. The school has won three NCAA national championships in men's fencing and one in women's fencing.