Palisade is a statutory town in Mesa County, Colorado, United States. It is part of the Grand Junction Metropolitan Statistical Area. The population was 2,565 at the 2020 census, down from 2,692 in 2010.

Mesa County is a county located in the U.S. state of Colorado. As of the 2020 census, the population was 155,703. The county seat and most populous municipality is Grand Junction. The county was named for the many large mesas in the area, including the Grand Mesa, which is the largest flat-topped mountain in the world.