Palmo's Opera House was a 19th-century theatre in Manhattan, New York, that was located on Chambers Street between Broadway and Centre Street. It was one of the earliest opera houses in New York before it was converted into one of the earliest Broadway theatres. The theatre was conceived by Ferdinand Palmo, an Italian immigrant and successful restaurateur in New York City. It was located inside the former Stoppani's Arcade Baths building. Modest alteration to the building was done in 1843 to convert the building into a theater.

Lucrezia Borgia is a melodramatic opera in a prologue and two acts by Gaetano Donizetti. Felice Romani wrote the Italian libretto after the play Lucrezia Borgia by Victor Hugo, in its turn after the legend of Lucrezia Borgia. Lucrezia Borgia was first performed on 26 December 1833 at La Scala, Milan.