Palo Duro Canyon is a canyon system of the Caprock Escarpment located in the Texas Panhandle near the cities of Amarillo and Canyon. As one of the largest canyons in the United States, it is roughly 25–40 mi (40–64 km) long and has an average width of 6 mi (9.7 km), but reaches a width of 20 mi (32 km) at places. Its depth is around 800 ft (240 m), but in some locations, valley bottom to surrounding hills increases to 1,000 ft (300 m). Palo Duro Canyon has been named "The Grand Canyon of Texas" both for its size and for its dramatic geological features, including the multicolored layers of rock and steep mesa walls, which are similar to those in the Grand Canyon. It is part of Palo Duro Canyon State Park. The State Park had 442,242 visitors in 2022.

Amarillo is a city in the U.S. state of Texas and the seat of Potter County. It is the 14th-most populous city in Texas and the most populous city in the Texas Panhandle. A portion of the city extends into Randall County. The estimated population of Amarillo was 200,393 as of April 1, 2020, comprising nearly half of the population of the panhandle. The Amarillo metropolitan area had an estimated population of 308,297 as of 2020.