The Palouse is a distinct geographic region of the northwestern United States, encompassing parts of north central Idaho, southeastern Washington, and, by some definitions, parts of northeast Oregon. It is a major agricultural area, primarily producing wheat and legumes. Situated about 160 miles (260 km) north of the Oregon Trail, the region experienced rapid growth in the late 19th century.

North Central Idaho is an area which spans the central part of the state of Idaho and borders Oregon, Montana, and Washington. It is the southern half of the state's Panhandle region and is rich in agriculture and natural resources. Lewis and Clark traveled through this area on their journey to the Pacific Ocean in September 1805, crossing Lolo Pass and continuing westward in canoes on the Clearwater River. They returned the following spring on their way eastward.