The Pan-American was a passenger train operated by the Louisville and Nashville Railroad (L&N) between Cincinnati, Ohio and New Orleans, Louisiana. It operated from 1921 until 1971. From 1921 to 1965 a section served Memphis, Tennessee via Bowling Green, Kentucky. The Pan-American was the L&N's flagship train until the introduction of the Humming Bird in 1946. Its name honored the substantial traffic the L&N carried to and from the seaports on the Gulf of Mexico. The Pan-American was one of many trains discontinued when Amtrak began operations in 1971.

The Louisville and Nashville Railroad, commonly called the L&N, was a Class I railroad that operated freight and passenger services in the southeast United States.