The Panama national football team represents Panama in men's international football and is governed by the Panamanian Football Federation. The team represents all three FIFA, CONCACAF and the regional UNCAF.

The 2018 FIFA World Cup was the 21st FIFA World Cup, the quadrennial world championship for national football teams organized by FIFA. It took place in Russia from 14 June to 15 July 2018, after the country was awarded the hosting rights in late 2010. It was the eleventh time the championships had been held in Europe, the first time they were held in Eastern Europe, and the first time they were held across two continents. At an estimated cost of over $14.2 billion, it was the most expensive World Cup ever held until it was surpassed by the 2022 World Cup in Qatar.