The rivalry between Panathinaikos and PAOK is the football rivalry between two of the most popular teams of the two biggest cities in Greece, the capital of Athens and Thessaloniki. In general terms, there is mutual respect between the two clubs and the rivalry has been focused mainly on the pitch throughout the decades. The Panathinaikos vs PAOK match is the most-played in Greek Alpha Ethniki/Super League history (1959–present) at 150 games.

PAOK, commonly known as PAOK Thessaloniki or simply PAOK, is a Greek professional football club based in Thessaloniki, Macedonia. PAOK are one of the top domestic clubs, the most widely supported in Northern Greece.