Panetolikos Football Club, or with its full name Panetolikós Yimnastikós Filekpedeftikós Síllogos, is a Greek professional football club. It was based in Agrinio, Greece. Panetolikos was founded in 1926 and is considered one of the historical clubs in Greece, currently participating in the Greek First Division. Some of the most well known players that started their career in the club are Stratos Apostolakis, former Greek recordman in international caps (96), and Petros Michos.

Agrinio is the largest city of the Aetolia-Acarnania regional unit of Greece and its largest municipality, with 89,691 inhabitants (2021). It is the economic center of Aetolia-Acarnania, although its capital is the town of Mesolonghi. The settlement dates back to ancient times. Ancient Agrinion was 3 kilometres northeast of the present city; some walls and foundations of which have been excavated. In medieval times and until 1836, the city was known as Vrachori (Βραχώρι).