Panhandle–Plains Historical Museum is a history museum located on the campus of West Texas A&M University in Canyon, Texas, United States, a small city south of Amarillo. The museum's contents are owned and controlled by the Panhandle-Plains Historical Society, while West Texas A&M University and the Texas A&M University Board of Regents maintain and provide the facilities. Panhandle–Plains Historical Museum is the largest history museum in the state of Texas with 70,000 visitors annually and more than three million artifacts.

West Texas A&M University is a public university in Canyon, Texas. It is the northernmost campus of the Texas A&M University System and accredited by the Southern Association of Colleges and Schools (SACS). It was established on September 20, 1910, as West Texas State Normal College as one of the seven state-funded teachers' colleges in Texas.