Panola County is a county located in the U.S. state of Mississippi. As of the 2020 census, the population was 33,208. Its county seats are Sardis and Batesville. The county is located just east of the Mississippi Delta in the northern part of the state. It is bisected by the Tallahatchie River flowing to the southwest; travel difficulties because of the river resulted in two county seats being established.

A county seat is an administrative center, seat of government, or capital city of a county or civil parish. The term is in use in five countries: Canada, China, Hungary, Romania, and the United States. An equivalent term, shire town, is used in the U.S. state of Vermont and in several other English-speaking jurisdictions. County towns usually serve a similar function in Ireland, Jamaica, and the United Kingdom.