Parktown Boys' High School is a public English medium high school for boys situated in Parktown, a suburb of Johannesburg in the Gauteng province of South Africa. It is one of the oldest schools in Johannesburg. Parktown Boys' sister school is Parktown High School for Girls.

Parktown is a wealthy suburb of Johannesburg, South Africa, and is the first suburb north of the inner city. It is affectionately known as one of the Parks, others including Parkview, Parkwood, Westcliff, Parktown North, Parkhurst and Forest Town. Parktown is one of Johannesburg's largest suburbs, neighbouring Hillbrow, Braamfontein and Milpark to the South; Berea and Houghton to the East; Killarney and Forest Town to the North, and Westcliff, Melville and Richmond to the West. Originally established by the Randlords in the 1890s, Parktown is now home to many businesses, hospitals, schools, churches and restaurants, whilst still maintaining quiet residential areas. It is also home to three of the five campuses of the University of the Witwatersrand including the education campus, medical school and Wits Business School. It is located in Region F of the City of Johannesburg Metropolitan Municipality.