Party and play (PnP), also known as chemsex or wired play, refers to the practice of consuming drugs to enhance sexual activity. This sexual subculture involves recreational drug users engaging in high-risk sexual behaviors under the influence of drugs, often within specific sub-groups. Activities may include unprotected sex with multiple partners during sessions over extended periods, sometimes lasting days. The drug of choice is typically methamphetamine, commonly referred to as crystal meth, tina, or T. Other substances like mephedrone, GHB, GBL, and alkyl nitrites are also used. The term slamsex is used for injection drug users.

Methamphetamine is a potent central nervous system (CNS) stimulant that is mainly used as a recreational drug and less commonly as a second-line treatment for attention deficit hyperactivity disorder and obesity. Methamphetamine was discovered in 1893 and exists as two enantiomers: levo-methamphetamine and dextro-methamphetamine. Methamphetamine properly refers to a specific chemical substance, the racemic free base, which is an equal mixture of levomethamphetamine and dextromethamphetamine in their pure amine forms, but the hydrochloride salt, commonly called crystal meth, is widely used. Methamphetamine is rarely prescribed over concerns involving human neurotoxicity and potential for recreational use as an aphrodisiac and euphoriant, among other concerns, as well as the availability of safer substitute drugs with comparable treatment efficacy such as Adderall and Vyvanse. Dextromethamphetamine is a stronger CNS stimulant than levomethamphetamine.