The Pascagoula River is a river, about 80 miles (130 km) long, in southeastern Mississippi in the United States. The river drains an area of about 8,800 square miles (23,000 km²) and flows into Mississippi Sound of the Gulf of Mexico. The Pascagoula River Basin is managed by the Pat Harrison Waterway District.

Escatawpa is an unincorporated community and census-designated place (CDP) in Jackson County, Mississippi, United States. It is part of the Pascagoula Metropolitan Statistical Area. The population was 3,254 at the 2020 census.