Paul Shaffer and the World's Most Dangerous Band is an American musical ensemble led by Paul Shaffer. It was David Letterman's house band for 33 years.

Paul Allen Wood Shaffer is a Canadian singer, composer, actor, author, comedian, and musician who served as David Letterman's musical director, band leader, and sidekick on the entire run of both Late Night with David Letterman (1982–1993) and Late Show with David Letterman (1993–2015).