The Pazzi conspiracy was a failed plot by members of the Pazzi family and others to displace the Medici family as rulers of Renaissance Florence.

The Pazzi were a powerful family in the Republic of Florence. Their main trade during the fifteenth century was banking. In the aftermath of the Pazzi conspiracy in 1478, members of the family were banished from Florence and their property was confiscated; the family name and coat-of-arms were permanently suppressed by order of the Signoria.