Pearisburg is a town in Giles County, Virginia, and the county seat. The population was 2,909 at the time of the 2020 census. Pearisburg is part of the Blacksburg–Christiansburg Metropolitan Statistical Area.

Giles County is a county located in the U.S. state of Virginia on the West Virginia state line. As of the 2020 census, the population was 16,787. Its county seat is Pearisburg.