The Pee Dee River, also known as the Great Pee Dee River, is a river in the Carolinas of the United States. It originates in the Appalachian Mountains in North Carolina, where its upper course, above the mouth of the Uwharrie River, is known as the Yadkin River. The river empties into Winyah Bay, and then into the Atlantic Ocean near Georgetown.

The Carolinas, also known simply as Carolina, is the term for the U.S. states of North Carolina and South Carolina, considered collectively. They are bordered by Virginia to the north, Tennessee to the west, and Georgia to the southwest. The Atlantic Ocean is to the east.