The Peirce–Nichols House is a historic house museum located at 80 Federal Street in Salem, Massachusetts. Designed early in the career of noted Salem builder Samuel McIntire (1757–1811), and modified later by him, the building gives a unique view into the methods and styles of McIntire. It was designated a National Historic Landmark in 1973 for its significance as an early masterwork of one of the country's first recognized master builders. It is now owned by the Peabody Essex Museum.

Salem is a historic coastal city in Essex County, Massachusetts, United States, located on the North Shore of Greater Boston. Continuous settlement by Europeans began in 1626 with English colonists. Salem was one of the most significant seaports trading commodities in early American history. Prior to the dissolution of county governments in Massachusetts in 1999, it served as one of two county seats for Essex County, alongside Lawrence.