Pekisko is an unincorporated community in southern Alberta, Canada. It is located in the Foothills County, east of the junction of Cowboy Trail and Highway 540, 35 kilometres (22 mi) south of High River and 19 km (12 mi) south of Longview.

Alberta Provincial Highway No. 22, commonly referred to as Highway 22 and officially named Cowboy Trail, is a 584-kilometre (363 mi) highway in the Canadian province of Alberta. It generally parallels Highway 2, beginning in the foothills of southern Alberta at Highway 3 near Lundbreck Falls. It proceeds north along the eastern slopes of the Rocky Mountains passing through the foothills and ranch country to the aspen parkland of northern Alberta, ending at Highway 18 near Mayerthorpe.