The Pelagonia Statistical Region is one of eight statistical regions of North Macedonia. It is located in southwestern part of the country along the eponymous plain. It borders Greece and Albania. Internally, it borders the Southwestern and Vardar statistical regions.

Pelagonia is a geographical region of Macedonia named after the ancient kingdom. Ancient Pelagonia roughly corresponded to the present-day municipalities of Bitola, Prilep, Mogila, Novaci, Kruševo, and Krivogaštani in North Macedonia and to the municipalities of Florina, Amyntaio and Prespes in Greece.