Pelzer is a town in Anderson County, South Carolina, United States, along the Saluda River. The population was 89 at the 2010 census, and grew to 1,344 at the 2020 census.

Anderson County is a county located in the U.S. state of South Carolina. As of the 2020 census, its population was 203,718. Its county seat is Anderson. Named for Revolutionary War leader Robert Anderson, the county is located in northwestern South Carolina, along the state line of Georgia. Anderson County is included in the Greenville-Anderson-Greer, SC Metropolitan Statistical Area. Anderson County contains 55,950-acre (22,640 ha) Lake Hartwell, a U.S. Army Corps of Engineers lake with nearly 1,000 miles (1,600 km) of shoreline for residential and recreational use. The area is a growing industrial, commercial and tourist center. It is the home of Anderson University, a private, selective comprehensive university of approximately 4,000 undergraduate and graduate students.