Pemba North Region or North Pemba Region is one of the 31 regions of Tanzania. The region covers an area of 574 km2 (222 sq mi). The region is comparable in size to the combined land area of the nation state of Saint Lucia. and the administrative region is located entirely on the island of Pemba. Pemba North Region is bordered to the north by Indian Ocean, south by Pemba South Region and the west by Pemba channel. The regional capital is Wete. According to the 2012 census, the region has a total population of 211,732.

Pemba Island is a Tanzanian island forming part of the Zanzibar Archipelago, lying within the Swahili Coast in the Indian Ocean.