Pembroke is a town in the Northern Region of Malta, and it is considered to be the country's newest locality. To the east is Paceville, the nightlife district of Malta. The coastal town and tourist hub of St. Julian's lies to the southeast, and the residential area of Swieqi lies to the south. The hilltop village of Madliena is to its west, and Baħar iċ-Ċagħaq lies to the northwest.

The Northern Region is one of six regions of Malta. The region includes the northwestern part of the main island of Malta. The region borders the Eastern, Southern and Western Regions, and is also close to Gozo Region.