Pembroke is a town in Giles County, Virginia, United States. The population was 1,128 at the 2010 census. It is part of the Blacksburg–Christiansburg Metropolitan Statistical Area.

Giles County is a county located in the U.S. state of Virginia on the West Virginia state line. As of the 2020 census, the population was 16,787. Its county seat is Pearisburg.