Pendleton County is a county located in the U.S. state of West Virginia. As of the 2020 census, the population was 6,143, making it the second-least populous county in West Virginia. Its county seat is Franklin. The county was created by the Virginia General Assembly in 1788 from parts of Augusta, Hardy, and Rockingham counties and was named for Edmund Pendleton (1721–1803), a distinguished Virginia statesman and jurist. Pendleton County was strongly pro-Confederate during the American Civil War; however, there were pockets of Unionists who supported the state government in Wheeling.

West Virginia is a landlocked state in the Southern and Mid-Atlantic regions of the United States. It is bordered by Pennsylvania to the north and east, Maryland to the east and northeast, Virginia to the southeast, Kentucky to the southwest, and Ohio to the northwest. West Virginia is the 10th-smallest state by area and ranks as the 12th-least populous state, with a population of 1,793,716 residents. The capital and most populous city is Charleston with a population of 49,055.