The Pennsylvania Ministerium was the first Lutheran church body in North America. With the encouragement of Henry Melchior Muhlenberg (1711–1787), the Ministerium was founded at a Church Conference of Lutheran clergy on August 26, 1748. The group was known as the "German Evangelical Lutheran Ministerium of North America" until 1792, when it adopted the name "German Evangelical Lutheran Ministerium of Pennsylvania and Adjacent States".

The Lutheran Theological Seminary at Philadelphia (LTSP) was one of eight theological seminaries associated with the Evangelical Lutheran Church in America, the largest Lutheran denomination in North America. It is located on Germantown Avenue in the Mount Airy neighborhood of northwestern Philadelphia. Founded in 1864, it has its roots in the Pennsylvania Ministerium established in 1748 in Philadelphia by Henry Melchior Muhlenberg.