Pennsylvania Route 150 is a 41.1-mile-long (66.1 km) highway in Central Pennsylvania. Its southern terminus is at PA 26 in Dale Summit, Pennsylvania near State College, at the location of the Nittany Mall. Its northern terminus is at U.S. Route 220 in Avis.

Pennsylvania Route 26 is a 125.5-mile (202.0 km) highway in the south-central area of Pennsylvania. Its northern terminus is at PA 150 northwest of Howard; its southern terminus is at the Maryland state line near Barnes Gap in Union Township. Two major destinations along this route are Raystown Lake near Huntingdon and the Pennsylvania State University at State College.