Pennsylvania Route 183 (PA 183) is a 31.7-mile-long (51.0 km) route that runs north to south in southeastern Pennsylvania. The southern terminus is at U.S. Route 422 Business in Reading in Berks County. Its northern terminus is at PA 61 near Schuylkill Haven in Schuylkill County. The road passes through developed areas near Reading before continuing north through rural areas, crossing from Berks County into Schuylkill County at Blue Mountain. PA 183 serves the communities of Bernville, Strausstown, and Cressona.

U.S. Route 422 Business is a 7.29-mile-long (11.73 km) business route of US 422 located in the Reading, Pennsylvania area. The route is one of four auxiliary routes of US 422 in Pennsylvania. Its western terminus is at an interchange with US 222 and US 422 in Wyomissing. Its eastern terminus is at an interchange with US 422 in Reiffton. US 422 Bus. heads east from US 222/US 422 along Penn Avenue, passing through Wyomissing and West Reading. The route has an interchange with the US 422 freeway before it crosses the Schuylkill River into Reading. US 422 Bus. passes through downtown Reading on the one-way pair of Franklin Street eastbound and Washington Street westbound, intersecting the southern terminus of Pennsylvania Route 183 and crossing US 222 Bus. The business route heads into the eastern part of the city southeast on Perkiomen Avenue before following the one-way pair of Perkiomen Avenue eastbound and Mineral Spring Road westbound into Mount Penn. US 422 Bus. continues along Perkiomen Avenue to St. Lawrence, where it intersects the western terminus of PA 562 and turns southeast. The route passes through Reiffton before it merges into eastbound US 422.