Pennsylvania Route 25 is a 35-mile-long (56 km) state highway located in Dauphin and Schuylkill counties in central Pennsylvania. The western terminus of the route is at U.S. Route 209 in Millersburg. The eastern terminus is at US 209 in Newtown. PA 25 runs parallel to the Mahantongo Mountains and the Mahantango Valley, as well as US 209, for its entire length. The route passes through the communities of Berrysburg, Gratz, Sacramento, and Hegins. PA 25 intersects PA 225 in Berrysburg, PA 125 in Hegins, and Interstate 81 (I-81) in Frailey Township. PA 25 was designated in 1928 to run from US 209 in Millersburg east to PA 443 in Pine Grove, running east to Hegins before heading southeast to Tremont and south to Pine Grove. The road between Hegins and Newtown was designated as PA 125. PA 25 was realigned to head east from Hegins to Newtown in the 1930s, with the former alignment between Pine Grove and Hegins becoming a relocated PA 125.

Pennsylvania Route 24 is a 29-mile-long (47 km) state highway located within central Pennsylvania in the York County area. Its southern terminus is at the Mason–Dixon Line near Stewartstown, where PA 24 continues into Maryland as Maryland Route 23. The northern terminus is at PA 921 in Mount Wolf. The route heads north from the state line through rural areas in southern York County, intersecting PA 851 in Stewartstown and PA 216 in Winterstown. PA 24 continues north to Red Lion, where it crosses PA 74 and intersects the south end of PA 624. The route runs through suburban areas to the east of York, crossing PA 124, PA 462, and U.S. Route 30. PA 24 continues north through rural land and reaches its end in Mount Wolf.