Pennsylvania Route 291 is an east–west state route in Pennsylvania that runs from U.S. Route 13 and US 13 Business in Trainer, Delaware County, east to Interstate 76 (I-76) in South Philadelphia near the Walt Whitman Bridge and the South Philadelphia Sports Complex. Except for a short 1-mile (1.6 km) section between the western terminus and the Chester/Trainer line, PA 291 is mostly a four-lane highway. From the western terminus to the eastern part of Chester, the route has a concurrency with US 13. It runs parallel to the Delaware River for much of the route. The route passes through industrial areas near the river in Delaware County, serving Chester, Eddystone, Essington, and Lester. PA 291 enters Philadelphia near the Philadelphia International Airport, at which point it has an interchange with I-95. The route crosses the Schuylkill River on the George C. Platt Memorial Bridge and continues along Penrose Avenue to I-76. It has been designated the Industrial Heritage Highway.

U.S. Route 13 (US 13) is a United States Numbered Highway running from Fayetteville, North Carolina, north to Morrisville, Pennsylvania. The route runs for 49.359 miles (79.436 km) through the Delaware Valley in the U.S. state of Pennsylvania. The route enters the state from Delaware in Marcus Hook, Delaware County. It continues northeast through Delaware County, passing through the city of Chester before heading through suburban areas along Chester Pike to Darby. US 13 enters the city of Philadelphia on Baltimore Avenue and runs through West Philadelphia to University City, where it turns north along several city streets before heading east across the Schuylkill River along Girard Avenue. The route turns north and heads to North Philadelphia, where it runs northeast along Hunting Park Avenue. US 13 becomes concurrent with US 1 on Roosevelt Boulevard, continuing into Northeast Philadelphia. US 13 splits southeast on a one-way pair of streets before heading northeast out of the city on Frankford Avenue. The route continues into Bucks County as Bristol Pike, heading northeast to Bristol, where it turns into a divided highway. US 13 becomes a freeway in Tullytown and continues north to its terminus at US 1 in Falls Township, near Morrisville. US 13 roughly parallels Interstate 95 (I-95) through its course in Pennsylvania.