Pennsylvania Route 297 (PA 297) is a 6-mile-long (9.7 km) state highway located in York County, Pennsylvania. The southern terminus is at PA 921 in Zions View. The northern terminus is at PA 262 in Cly. PA 297 is a two-lane undivided road in the northern section of York County. The route heads north along Susquehanna Trail a short distance to the west of Interstate 83 (I-83) before reaching an interchange with the highway and heading to the east of it. PA 297 turns northeast in Strinestown and crosses PA 382 before it comes to its northern terminus.

York County is a county in the Commonwealth of Pennsylvania, United States. As of the 2020 census, the population was 456,438. Its county seat is York. The county was created on August 19, 1749, from part of Lancaster County and named either after the Duke of York, an early patron of the Penn family, or for the city and county of York in England. The county is part of the South Central region of the state.