Pennsylvania Route 309 is a state highway that runs for 134 miles (216 km) through eastern Pennsylvania. The route runs from an interchange between PA 611 and Cheltenham Avenue on the border of Philadelphia and Cheltenham Township north to an intersection with PA 29 in Bowman Creek, a village in Monroe Township in Wyoming County. The highway connects Philadelphia and its northern suburbs to Allentown and the Lehigh Valley, and Hazleton and Wilkes-Barre in Wyoming Valley.

Wilkes-Barre is a city in and the county seat of Luzerne County, Pennsylvania, United States. Located at the center of the Wyoming Valley in Northeastern Pennsylvania, it had a population of 44,328 in the 2020 census. It is the second-largest city, after Scranton, in the Scranton–Wilkes-Barre–Hazleton, PA Metropolitan Statistical Area, which had a population of 567,559 as of the 2020 census, making it the fifth-largest metropolitan area in Pennsylvania after the Delaware Valley, Greater Pittsburgh, the Lehigh Valley, and Greater Harrisburg.